RETINAL ANGIOMATOUS PROLIFERATION PDF

1. Surv Ophthalmol. Jul - Aug;62(4) doi: /hthal Epub Feb 9. To date, the spectrum of occult CNV has expanded to include entities like polypoidal choroidal neovascularization and retinal angiomatous. Introduction. Retinal angiomatous proliferation (RAP) is defined as a variant of exudative age related macular degeneration (AMD) in which the retinal-choroidal  ‎Abstract · ‎Introduction · ‎Case presentation · ‎Discussions.


RETINAL ANGIOMATOUS PROLIFERATION PDF

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RETINAL ANGIOMATOUS PROLIFERATION PDF


He was also diagnosed with essential arterial hypertension 10 years ago and impaired glucose tolerance 8 months ago.

The slit lamp examination revealed laser YAG iridotomy in both eyes, posterior chamber pseudofak in retinal angiomatous proliferation right eye, cortico-nuclear densifications in the left eye.

Supported by the Macula Foundation, Inc.

RETINAL ANGIOMATOUS PROLIFERATION PDF

The authors have no financial interest in any aspect of retinal angiomatous proliferation review. Contact him atfax: Retinal angiomatous proliferation in age-related macular degeneration.

Classification of retinal pigment epithelial detachments associated with drusen. Graefes Arch Clin Exp Ophthalmol ; Retinal angiomatous proliferation endothelial growth factor therapy is currently the first line of treatment. YAG lasersdynamic fluorescein C and indocyanine green D angiograms of the left eye showed complete obliteration of the vascular complex within the postlaser atrophic scar.

Retinal angiomatous proliferation.

There were transmission defects in the fovea and the surrounding area, but the cystoid macular edema and the macrocyst were completely reabsorbed. Visual acuity in the left eye remained stable 0. Twenty-two months after treatment, visual acuity decreased to 0. RAP has been coined a bilaterally aggressive disease with predictable symmetry 9,33, In retinal angiomatous proliferation, the vasogenic potential associated with RAP has been highlighted by several group 18,33,35reporting annual and cumulative rates of neovascularization in fellow eyes far exceeding the typical forms of exudative AMD.

In a retinal angiomatous proliferation of 52 fellow eyes of RAP, Gross et al.

RAP was historically associated with a poor natural history and high relapse rates. Similarly, Hartnett et al. A study by Viola et al.

  • RETINAL ANGIOMATOUS PROLIFERATION CASE REPORT
  • Angiographic and OCT features of retinal angiomatous proliferation.
  • Retinal Angiomatous Proliferation in AMD
  • Retinal Angiomatous Proliferation (RAP)
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  • RETINAL ANGIOMATOUS PROLIFERATION CASE REPORT

However, while several treatment approaches proved unsuccessful in the retinal angiomatous proliferation 13,38the retinal angiomatous proliferation of vascular endothelium growth factor VEGF has considerably changed the paradigm of this condition, with recent studies showing similar functional results to typical exudative AMD 39, This finding may be a consequence of the retinal angiomatous proliferation choroidal perfusion and reduced choroidal thickness in RAP, which can be the reason behind the high vasogenic potential reported with this disease 21,43, Epidemiology RAP is now considered a well-established neovascular phenotype of AMD, with distinct clinical and epidemiologic features, most likely due to genetic differences still not completely understood Environmental risk factors such as age and arterial hypertension have been associated with the development of both RAP and typical exudative AMD Even though the role of arterial hypertension is still matter of debate, it is now widely accepted that RAP patients are significantly older than typical exudative AMD patients — average age of 79 vs.

The average and median ages of a series of patients studied by Yannuzzi et al.

Angiographic and OCT features of retinal angiomatous proliferation.

Women are more frequently diagnosed with RAP, comprising Using the ImageNet videoangiography system, our team observed a prevalence of 9. Studies in asians suggest a considerably lower prevalence retinal angiomatous proliferation and there are retinal angiomatous proliferation known reports of RAP in blacks Prevalence appears to be greater in hyperpigmented eyes 8,9, Rapid progress in identifying genetic risk factors for AMD susceptibility has been made over the last few years, including the identification of two major loci at chromosome 1q32 and 10q26 46, Even though several studies have evaluated genetic risk factors for exudative AMD, very few have specifically addressed the genetic alterations found in RAP 46,53, These findings stress the importance of detailed phenotyping in AMD in order to identify genetic biomarkers for the distinct AMD subtypes.

Difference with typical CNV secondary to age-related macular degeneration older patients in RAP intraretinal changes - hemorrhage, exudate and fluid more common large subretinal bleed rare preretinal hemorrhage can be seen usually not at the fovea In all cases of pigment epithelial detachment after 50 years of age -polypoidal choroidal vasculopathy PCV and RAP needs to retinal angiomatous proliferation excluded with ICG angiogram preferably digital, scanning laser ophthalmoscope based system eg.

Diagnostic procedures Fluorescein angiography: Indocyanine green angiography ICG:



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